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Ivermectin is active against various life-cycle stages of many but not all nematodes. It is active against the tissue microfilariae of Onchocerca volvulus but not against the adult form. Its activity against Strongyloides stercoralis is limited to the intestinal stages.

Once the worms end up in your stomach, they move to your small intestine where they lay eggs and hatch to become larvae. These larvae can be expelled through your feces or penetrate the perianal skin or burrow into the intestinal wall. This is called an auto-infection and you may require treatment for a long period of time should your infection turn into a hyper-infection.

Ivermectin is a member of the avermectin class of broad-spectrum antiparasitic agents which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

Warnings: Do not take Stromectol if: you have an allergy to Stromectol or any of the ingredients listed, the packaging is torn or shows signs of tampering, the expiry date on the pack has passed. If you take this medicine after the expiry date has passed, it may not work.